Complement receptors encompass at least eight proteins from four structural classes, orchestrating complement-mediated humoral and cellular effector responses and coordinating the complex cross …
Human complement receptor 1 (HuCR1) is a pivotal regu-lator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay …
The function of CRI in the kidney remains unknown, and the receptor may not be essential since it is not present in nonprimate glomeruli; thus, the consequences of its early appearance in the human …
Complement factor C5a is an integral constituent of the complement cascade crit-ically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2.
Here we address the GWAS hit CR1. CR1 is a membrane receptor that controls complement activation by accelerating decay of the C3 convertase and acting as a co-factor for factor I (FI)-mediated …
Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and …
It mediates a variety of functions that include phagocytosis and regulation of the complement cascade. This receptor has been cloned and the primary structure reveals that the cell- bound molecule is an …