The system that allows the sharing of genetic material between bacteria – and therefore the spread of antibiotic resistance – has been uncovered by a team of scientists at Birkbeck, University of ...

Many pathogenic bacteria use special secretion systems to deliver toxic proteins into host cells. Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have determined the structure of a ...

Bacteria have complex molecular machines that help them drive disease. Scientists can now leverage these machines to treat disease instead. We primarily work with nanobodies, although we have shown ...

Some bacteria are known to inject toxins into host cells using a syringe-like appendage. Past research has found that we might be able to hijack that as a new drug delivery system, and now scientists ...

Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...

Gut bacteria aren’t just passive passengers—they can actively send proteins straight into our cells. Using microscopic injection systems, even harmless microbes can influence immune responses and ...

Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the ...

Bacteria in the human gut can directly deliver proteins into human cells, actively shaping immune responses. Led by researchers at Helmholtz Munich, with participation from Ludwig Maximilians ...

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years. Now Niederweis ...